Now using Terminal, you must set the appropriate access permissions on the new file you have created, so that it will run properly on startup. The system may ask for your password to save the file here if you're using Finder to do so. This file should then be saved to the following directory, I used the filename '': /Library/LaunchDaemons Replace 'root' with a valid admin UserName. Applications/ColdFusion11/cfusion/bin/coldfusion To do so you must create an XML / text file as follows: The preferred method is by using Launch Daemons. You will see that both ColdFusion and MySQL (if you have it installed) have created startup items - however that functionality has been deprecated by Apple (see Mac Developer Library: Startup Items) so the services do not startup automatically as desired. Selecting a region changes the language and/or content on is the same issue as MySQL suffers.